Antibacterial Peptides

                                                                                                                                                                                                                                  Download data

Antimicrobial peptide KLKLLLLLKLK-NH2 and its D-enantiomerSignificant chemotherapeutic activity in MRSA-infected miceChemotherapeutic activity of synthetic antimicrobial peptides: correlation between chemotherapeutic activity and neutrophil-activating activity9326370
Protegrin-1CONCLUSIONS: This study shows that protegrin-1 potentially may be used as an alternative or adjunct therapy to standard agents used to treat wound infections.11445704
Brevinin-2 peptides from the skin of the Hokkaido frog, Rana piricaThe most abundant peptide, brevinin-2PRa (680 nmol/g weight of dry skin) showed high potency [minimal inhibitory concentration (MIC) values between 6 and 12 microM] against a range of clinical isolates of P. aeruginosa.A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. Nine peptides displaying varying degrees of antimicrobial activity were extracted from the skin of the Hokkaido frog, Rana pirica.15003829
Antimicrobial peptide, human lactoferrin 1-11 (hLF1-11)The hLF1-11-treated group also had a significantly lower radiological score compared to the gentamicin-treated group. This study demonstrates the efficacy of hLF1-11 incorporated into Ca-P bone cement as a possible therapeutic strategy for the treatment of osteomyelitis, showing efficacy comparable to that of gentamicin.15917544
[fMLF]PMBN and [fMLF]PMENNeopeptide antibiotics that function as opsonins and membrane-permeabilizing agents for gram-negative bacteria16048913
PhenothiaziniumWe used MDR-deficient mutants of Staphylococcus aureus (NorA), Escherichia coli (TolC), and Pseudomonas aeruginosa (MexAB) and found 2 to 4 logs more killing than seen with wild-type strains by use of three different phenothiazinium PSs and red light.: Mutants that overexpress MDRs were protected from killing compared to the wild type.Antimicrobial photodynamic therapy (PDT) combines a nontoxic photoactivatable dye, or photosensitizer (PS), with harmless visible light to generate singlet oxygen and free radicals that kill microbial cells.Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps. Antimicrobial photodynamic therapy (PDT) combines a nontoxic photoactivatable dye, or photosensitizer (PS), with harmless visible light to generate singlet oxygen and free radicals that kill microbial cells.16377686
Natural toxins and animal venoms (snakes, scorpions and honey bee venoms)Antimicrobial activity against Burkholderia pseudomalleiIn vitro antimicrobial activity of natural toxins and animal venoms tested against Burkholderia pseudomallei16784542
Antimicrobial peptides (AMPs), UBI 1-59 and synthetic fragments comprising amino acids 31-38In vitro killing of MRSA by synthetic peptides derived from the alpha-helix or beta-sheet domains of the human cationic peptide ubiquicidin (UBI 1-59), allowed selection of AMPs for possible treatment of MRSA infections. The strongest antibacterial activity was observed for the entire peptide UBI 1-59 and for synthetic fragments comprising amino acids 31-38.The availability, chemical synthesis opportunities, and size of these small peptides, combined with their strong antimicrobial activity towards MRSA make these compounds promising candidates for antimicrobial therapy and detection of infections in man. 16814900
Hyaluronic acid binding peptidesEffective in experimental surgical wound infections caused by S. aureusTreatment with these peptides was highly efficacious in reducing the number of S. aureus cells at the wound site and ameliorated the inflammatory host response associated with these infections.17065624
Defr1, covalent dimer species of beta-defensinAntimicrobial activity against Pseudomonas aeruginosa PAO1 and an extended panel of multidrug-resistant nosocomial pathogensCovalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens. Beta defensins comprise a family of cationic, cysteine-rich antimicrobial peptides, predominantly expressed at epithelial surfaces.17353239
Lipopeptides Pal-Lys-Lys-NH(2) and Pal-Lys-Lys soaking alone and in combination with intraperitoneal vancomycinVancomycin combined to Pal-Lys-Lys-NH(2) exerted the strongest anti-staphylococcal efficacies. The in vitro studies showed, that MIC and MBC values for vancomycin were lower in presence of lipopeptides. They reduce the bacterial load and to enhance the effect of vancomycin in the prevention of vascular graft staphylococcal infections.The lipopeptides Pal-Lys-Lys-NH(2) and Pal-Lys-Lys soaking alone and in combination with intraperitoneal vancomycin prevent vascular graft biofilm in a subcutaneous rat pouch model of staphylococcal infection.17537542
Antimicrobial peptide thionin Thi2.1Growth inhibition of S. aureus isolates was dose-dependent, showing a total inhibition at concentrations higher than 3.12 microg/ml.Antibacterial activity of thionin Thi2.1 from Arabidopsis thaliana expressed by bovine endothelial cells against Staphylococcus aureus isolates from bovine mastitis. Bovine mastitis is mainly caused by Staphylococcus aureus and antimicrobial therapy, commonly used for its control, has resulted in an increase in the frequency of resistant staphylococci in recent years.17961938
AP-CECT7121 (an antimicrobial peptide isolated from an environmental strain of Enterococcus faecalis CECT7121)Activity against Enterococcus faecium, Enterococcus faecalis,Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Clostridium perfringens and Clostridium difficileCONCLUSIONS: AP-CECT7121 may provide a novel strategy for treating potentially fatal clinical infections in hospitalized patients.19494489
ArmininMinimal bactericidal concentration, 0.4 microM to 0.8 microM against multiresistant human pathogenic strains, such as methicillin-resistant Staphylococcus aureus (MRSA) strainsActivity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources19770277
Laterocidin and its analogues [3 (Asp(1)-->Asn(1), Phe(4)-->Tyr(4) and d-Tyr(6)-->d-Phe(6))]Antimicrobial properties, against clinical Methicillin-resistant Staphylococcus aureus (L-MRSA) and the gram-negative extended-spectrum beta-lactamases-producing Escherichia coli (ESBLs E. coli) and L-E.coli.Solid-phase synthesis and antibiotic activities of cyclodecapeptides on the scaffold of naturally occurring Laterocidin19932962
longicornsinStrong antimicrobial ability against drug-resistant microorganisms and Helicobacter pyloriA novel defensin-like peptide from salivary glands of the hard tick, Haemaphysalis longicornis20027626
Alyteserin-1c (GLKEIFKAGLGSLVKGIAAHVAS?NH(2)) and its analoguesAlyteserin-1c displayed MIC=5-10 micro M; minimum bactericidal concentration, MBC=5-10 microM), increasing the cationicity of alyteserin-1c by the substitution Glu(4)->Lys enhanced the potency (MIC=1.25-5 micro M; MBC=1.25-5 micro M) against MDRABalyteserin-1c (LD(50)=220 ?M)and its catonic analogues (HC(50)>400 ?M) has low hemolytic activity against human erythrocytes , and.Potent and rapid bactericidal action of alyteserin-1c and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii20603168
Hominicin (DmIle-Dhb-Pro-Ala-Dhb-Pro-Phe-Dhb-Pro-Ala-Ile-Thr-Glu-Ile-Dhb-Ala-Ala-Val-Ile-Ala -Dmp)Potent activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus (MRSA) ATCC 11435 and vancomycin-intermediate S. aureus (VISA) CCARM 3501Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9.20654578
Acyldepsipeptide 4 (ADEP 4) analog in which the pipecolate was replaced by 4-methyl pipecolatein vitro antibacterial activity against Enterococci that was fourfold higher than the parent compound ADEP 4Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent.20833054
PTP-7, lytic peptideAnti-biofilm activity, potent to Gram-positive bacteria and is able to kill antibiotic sensitive and resistant Staphylococcus aureusThe activity of a small lytic peptide PTP-7 on Staphylococcus aureus biofilms21887652
C(12)K-2?(12), oligo-acyl-lysyl (OAK) antimicrobial peptidomimeticA dual mode of action against the H. pylori membrane and cytoplasmic componentsThe oligo-acyl lysyl antimicrobial peptide C(12)K-2?(12) exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori22064541
Epidermicin NI01Potent antimicrobial activity toward a wide range of pathogenic Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), enterococci, and biofilm-forming S. epidermidis strainsIdentification, characterization, and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis that displays potent activity against Staphylococci.22155816
CPF-AM1, PGLa-AM1, B2RP-ERa, [E4K]alyteserin-1c, [D4K]B2RP and [G4K]XT-7Overall colistin-susceptibleminimum inhibitory concentration against colistin-susceptible (MIC) ? 2 micro g/mL] and colistin-resistant (MIC ? 64 micro g/mL) clinical isolates of multidrug-resistant strains of Acinetobacter baumannii and Acinetobacter nosocomialis, with most potent peptides being [D4K]B2RP and [E4K]alyteserin-1c (MIC=4-16 micro g/mL)low haemolytic activity against human erythrocytes.Efficacy of six frog skin-derived antimicrobial peptides against colistin-resistant strains of the Acinetobacter baumannii group22326566
OH-CATH30 and its analog OH-CM6The MICs of OH-CATH30 and OH-CM6 ranged from 1.56 to 12.5 micro g/ml against drug-resistant clinical isolates of several pathogenic species, including Escherichia coli, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus.relatively low toxicity and potent efficacy in mouse modelsEfficacy of OH-CATH30 and its analogs against drug-resistant bacteria in vitro and in mouse models.22491685
Dimeric PpIX-YI13WF (photosensitizer protophophyrin IX - YI13WF (YVLWKRKRKFCFI-Amide)) conjugate(MIC) values of dimeric PpIX-YI13WF conjugate itself observed for E. coli DH5a (~4 times), S. enterica (~8 times), and other Gram-negative strains including antibiotic-resistant E. coli BL21 (~8 times) and K. pneumoniae (~16 times).Dimeric PpIX-YI13WF conjugate could selectively recognize bacterial strains over mammalian cells and generate less photo damage to mammalian cells.Lipopolysaccharide neutralizing peptide-porphyrin conjugates for effective photoinactivation and intracellular imaging of gram-negative bacteria strains. A simple and specific strategy based on the bioconjugation of a photosensitizer protophophyrin IX (PpIX) with a lipopolysaccharide (LPS) binding antimicrobial peptide YI13WF (YVLWKRKRKFCFI-Amide) has been developed for the effective fluorescent imaging and photodynamic inactivation of Gram-negative bacterial strains.22769015
Peptide conjugated phosphorodiamidate morpholino oligomersPeptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis. Targeting bacterial essential genes using antisense phosphorodiamidate morpholino oligomers (PMOs) represents an important strategy in the development of novel antibacterial therapeutics.22978365
PEP6R (VKVRVRVRV(D)PPTRVRVRVKV)High potency against bacteriacytocompatible toward human erythrocytes as well as mammalian mesenchymal stem cellsArginine-rich self-assembling peptides as potent antibacterial gels.22995710
PXL150In vitro a broad spectrum microbicidal action against both Gram-positive and Gram-negative bacteria, including resistant strainsThe novel antimicrobial peptide PXL150 in the local treatment of skin and soft tissue infections.23053090
NK-18Two targets, acts on bacterial membrane and DNA in the cytoplasmThe double targets of NK-18 make it difficult for bacteria to generate resistance, which may present a new strategy to defend against multidrug-resistant bacteria and provide a new lead in the design of potent antimicrobial peptides with therapeutic application in the presence of increasing resistance to conventional antibiotics.23089755
LL-37Effective in killing extracellular S. aureus at nanomolar concentrationsTherefore, LL-37 was shown to be very potent and prompt in eliminating both extra- and intracellular S. aureus and was more effective in killing extra- and intracellular S. aureus than commonly used conventional antibiotics.23274662
TSG-8-1, WWSYVRRWRSR-amideAntimicrobial activity against E. coli and S. aureusVery little hemolytic activity in human erythrocytes t high dose levelStructure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide23570790
S-thanatinHigh activity of S-thanatin against K. pneumoniae in vitro with MIC between 4 and 8 micro g/ml.?All above implied that S-thanatin, as an alternative, may provide a novel strategy for treating K. pneumoniae infection and other infections due to multidrug-resistant bacteria.23643614
Peptidomimetics (Short histidine-derived antimicrobial peptides (SAMPs))High antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA)No hemolytic activityNon hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents.23816372
R-thanatinPotent in vitro activity against coagulase-negative staphylococci, such as S. epidermidis, S. haemolyticus, and S. hominis, and inhibited biofilm formation at subinhibitory concentrationsR-thanatin inhibits growth and biofilm formation of methicillin-resistant Staphylococcus epidermidis in vivo and in vitro23917310
C5a-derived immunobiotic peptide EP67EP67 inhibits GBS growth in vitro and in vivo and that antibacterial activity was specific to Streptococcus species.We have employed a host-directed immunomodulatory therapy using a novel peptide, known as EP67, derived from the C-terminal region of human complement component C5a.23979760
Hymenochirin-1B (IKLSPETKDN(10)LKKVLKGAIK(20)GAIAVAKMV.NH2) analogue in which the Pro(5), Glu(6) and Asp(9) on the hydrophilic face of the ?-helix are substituted by one or more l-lysine or d-lysine residues[E6k,D9k]hymenochirin-1B has MIC in the range 0.8-3.1 micro M against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and a range of Gram-negative bacteria, including multidrug-resistant strains of Acinetobacter baumannii and Stenotrophomonas maltophilia, MIC in the range 3.1-6.25 micro M against NDM-1 carbapenemase-producing clinical isolates of Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae and Citrobacter freundii.,low hemolytic activity (LC50=302 ?M) of [E6k,D9k]hymenochirin-1BAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties24172540
BmKn2 scorpion venom peptide and its derivativesBactericidal, potent activity against N. gonorrhoeae with MIC50 values of 6.9-27.6 ?MPotent and rapid antigonococcal activity of the venom peptide BmKn2 and its derivatives against different Maldi biotype of multidrug-resistant Neisseria gonorrhoeae.24184420
His-derived antimicrobial peptides (HDAMPs)Promising dual antimicrobial and anti-inflammatory activities, as well as anti-methicillin-resistant Staphylococcus aureus (MRSA) activityCONCLUSION/SIGNIFICANCE: The combination of the ultra-short size, high-prokaryotic selectivity, potent anti-MRSA activity, anti-inflammatory activity, and proteolytic resistance of the designed HDAMP-1, -3, -5, and -6 makes these molecules promising candidates for future antimicrobial therapeutics.24302996
Temporin-SHa (FLSGIVGMLGKLF amide)Broad-spectrum activity against Gram-positive and Gram-negative bacteria, yeasts and parasitesTemporin-SHa (FLSGIVGMLGKLF amide) is a small hydrophobic and low cationic antimicrobial peptide with potent and very broad-spectrum activity against Gram-positive and Gram-negative bacteria, yeasts and parasites.24919960
Pandinin 2 variantsAntimicrobial activity against E. coli, S. aureus, and M. tuberculosisPin2 [14] presented only 25% of hemolysis toward human erythrocytes at concentrations as high as 100 ?M, while the peptide Pin2 [17] did not show any hemolytic effect at the same concentrationTherefore, Pin2 [14] and Pin2 [17] have the potential to be used as an alternative antibiotics and anti-tuberculosis agents with reduced hemolytic effects.25019413
Peptides human beta-defensin-3 (hBD-3) and cathelicidin (LL-37)Non-cytotoxic concentrations of hBD-3 (10 and 20 micro M) and LL-37 (0.1 and 0.2 micro M)This combination of antimicrobial peptides thus shows promising potential as an adjunctive therapy for treating inflammatory periodontitis.25187958
l isomer of lycosin-I (l-lycosin-I), d isomer of lycosin-I (d-lycosin-I), l- and d-amino acid residues of RKGWFKAMKSIAKFIAKEKLKEHLThe MICs of the three isomers of lycosin-I and several other clinical drugs were determined through the broth microdilution method in accordance with the CLSI protocolThese two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg(2+) or Ca(2+)) concentrations.25199777
G(IIKK)(3)I-NH(2)Effective against ESBL-producing bacterial infectionmultidrug resistant ESBL-producing bacteria do not develop resistance and low toxicity toward mammalian hostsHigh cell selectivity and low-level antibacterial resistance of designed amphiphilic peptide G(IIKK)(3)I-NH(2). On the basis of cell cultures involving bacterial strains (Escherichia coli 5? and Bacillus subtilis 168) and a mammalian cell line (NIH 3T3), the potent antibacterial activity and distinct selectivity from designed amphiphilic peptides G(IIKK)nI-NH2 (n = 2-4) have been demonstrated.25210781
Antimicrobial peptides (AMPs) GPPPQGGRPQG and RFGYGYGPYQPVPEQPLYPQAntibacterial effect in S. aureusThese showed to exert an antibacterial effect in Staphylococcus aureus. This report validates the prospection of mammal's saliva to find new alternatives to antibiotics.BIOLOGICAL SIGNIFICANCE: With the growing problem of antibiotic resistance, the identification of new routes in antibiotic therapy is on the scientific agenda worldwide.25534884
VRV-PL-V (Vipera russellii venom phospholipase A2 fraction V) of Daboia russellii pulchella venomAntibacterial activity with MIC values ranging from 13 to 24 micro g/mlVRV-PL-V demonstrated a potent antibacterial activity against all the human pathogenic strains tested.25540009
Tilapia piscidin antimicrobial peptides TP3 (H-FIHHIIGGLFSVGKHIHSLIHGH-OH), TP4 (H-FIHHIIGGLFSAGKAIHRLIRRRRR-OH)TP4 MIC against K. pneumonia and A. baumannii in the range < 1.56 microg/mL - 3.125 microg/mL. TP3 MIC against K. pneumonia and A. baumannii in the range < 1.56 microg/mL - 25 microg/mLTP3 and TP4 are able at potentiate anti-Acinetobacter baumannii or anti-Klebsiella pneumonia drug activity, reduce bacterial load, and prevent drug resistance, indicating their potential for use in combating multidrug-resistant bacteria.25874924
VG16KRKPAntimicrobial activity against Gram-negative E. coli and plant pathogens X. oryzae and X. campestris, as well as against human fungal pathogens C. albicans and C. grubii.The de novo design of VG16KRKP provides valuable insights into the development of more potent antibacterial and antiendotoxic peptides for the treatment of human and plant infections.26144972
Synthetic peptides based on LF11( LF11-215 (FWRIRIRR), LF11-227 (FWRRFWRR), DI-MB-LF11-322 (2,2-dimethylbutanoyl-PFWRIRIRR) and DI-MB-LF11-215)Potent anti-biofilm activity against Pseudomonas aeruginosaAntimicrobial activity of synthetic cationic peptides and lipopeptides derived from human lactoferricin against Pseudomonas aeruginosa planktonic cultures and biofilms26149536
NLF20 (NLFRKLTHRLFRRNFGYTLR)Potent antimicrobial effects against the Gram-negative bacteria Escherichia coli and P. aeruginosa, the Gram-positive Bacillus subtilis and Staphylococcus aureus and the fungi Candida albicans and Candida parapsilosisNLF20: an antimicrobial peptide with therapeutic potential against invasive Pseudomonas aeruginosa infection26503666
K1K8: an Hp1404-derived antibacterial peptideDecreased methicillin-resistant Staphylococcus aureus (MRSA) bacterial counts in the wounded region in a mouse skin infection modelLow hemolytic activityK1K8: an Hp1404-derived antibacterial peptide. As an alternative class of antimicrobial agents used to overcome drug-resistant infections, antimicrobial peptides (AMPs) have recently gained significant attention.26952110
D-L91 (SEFAYGSFVRTVSLPVGADE)Enhancement of IFN-gamma(+)TNF-alpha(+) polyfunctional Th1 cells and IL-17A(+)IFN-gamma(+) Th17 cells, enduring memory CD4 T cells and downregulation of PD-1The adjunct therapy using drugs and L91 (D-L91) significantly declined the bacterial load in Mtb infected animals.27052185
CSpK14 , antimicrobial peptideMICs reduced by 8- to 64-fold and 2- to 16-fold in combination wth oxacillin and ampicillin respectivelyCSpK14 was simple to purify, had low molecular mass, was stable over a wide pH range or tested chemicals, had broad inhibitory spectrum, and possessed potent synergistic antimicrobial-antibiofilm properties.27787755
Series of side-chain hybrid dimer peptides J-AA (Anoplin-Anoplin), J-RR (RW-RW), and J-AR (Anoplin-RW) based on the wasp peptide Anoplin and the arginine- and tryptophan-rich hexapeptideDesign of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy.28040477
Thiazomycin, nocathiacin and analogsActivity against drug resistant Mycobacterium tuberculosis with different MICsThiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis. Thiazolyl peptides are a class of natural products with potent Gram-positive antibacterial activities.28096545
Heterofunctionalized poly(ethylene glycol) with different lengths (methacrylate-PEGn-tosyl, n=10/45/90) conjugated with polypeptides to form diblock amphiphilesAntimicrobial activity against several pathogenic bacteria like Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and effectively prevent biofilm formationThus, this facilely synthesized PEGylated AMP bottlebrush coating is a feasible method to prevent biomedical devices-associated infections.28131941
[K3]SHa[K3]SHa emerged as a highly potent compound active against a wide range of bacteria, yeasts/fungi, and trypanosomatids (Leishmania and Trypanosoma), with leishmanicidal intramacrophagic activity and efficiency toward antibiotic-resistant strains of S. aureus and antimony-resistant L. infantum.To improve activity, we designed analogs of SHa and compared the antibacterial and antiparasitic mechanisms. [K3]SHa emerged as a highly potent compound active against a wide range of bacteria, yeasts/fungi, and trypanosomatids (Leishmania and Trypanosoma), with leishmanicidal intramacrophagic activity and efficiency toward antibiotic-resistant strains of S. aureus and antimony-resistant L. infantum.28319176
Cecropin A2Synergistic Efficacy in combination with Tetracycline against Pseudomonas aeruginosaSynergistic Efficacy of Aedes aegypti Antimicrobial Peptide Cecropin A2 and Tetracycline against Pseudomonas aeruginosa.28483966
Sph12-38MIC 3 micro M against Staphylococcus aureus, Corynebacterium glutamicum, Micrococcus lysodeikticus Fleming, Bacillus subtilis, Pseudomonas fluorescens, Aeromonas hydrophila and A. sobriaTaken together, the synthetic peptide of Sph12-38 had a potent antimicrobial activity against bacteria.28600196
Free or anchored antimicrobial peptides like the cathelicidins BMAP-27 and BMAP-28, their (1-18) fragments and the rationally designed, artificial P19(9/G7) peptideEffective at micromolar concentrations against 22 Staphylococcus and Streptococcus isolates from orthopaedic infections, BMAP-28 and to a lesser extent BMAP-27 were active against Enterococcus faecalisNegligible toxicity towards osteoblastsAlpha-helical antimicrobial peptides (AMPs) may be promising candidates in this respect due to their potent and broad-spectrum antimicrobial activity, their low tendency to elicit resistance and possible retention of efficacy in the immobilized state.28707817
NZ2114 and MP1102The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. perfringens type A strain CVCC 46 were 0.91 micro MMode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A. .28934314
Antimicrobial peptide Brevinin-2Ta (GILDTLKNLAKTAGKGILKSLVNTASCKLSGQC)MIC of B-2Ta against S. aureus 64 mg/L, E. coli 32 mg/L, C. albicans 64 mg/L.Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats. Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates.29340060
Histone H5 purified from chicken erythrocytesActive against Gram-positive and Gram-negative planktonic bacteria (MIC range: 1.9 +- 1.8 to 4.9 +- 1.5 micro g/mL)Histone H5 is a potent Antimicrobial Agent and a template for novel Antimicrobial Peptides. Modern medicine is challenged continuously by the increasing prevalence of antibiotic resistant bacteria.29402952
OH-CATH30 (L and D)highest bactericidal activity against Acinetobacter spp., including multi-drug-resistant Acinetobacter baumannii (MRAB) and methicillin-resistant Staphylococcus aureus (MRSA)King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates. Cationic antimicrobial peptides (AMPs) are considered as important candidate therapeutic agents, which exert potent microbicidal properties against bacteria, fungi and some viruses.29515090
Pituitary adenylate cyclase-activating polypeptide (PACAP)Antimicrobial activity against Escherichia coli and Staphylococcus aureusPituitary adenylate cyclase-activating polypeptide (PACAP) is a naturally occurring cationic peptide with potent immunosuppressant and cytoprotective activities.29654809
Myristoylation of Human alpha-Defensin 5Our strategy involves the myristoylation of human alpha-defensin 5 (HD5) as a therapeutic target and subsequent self-assembly in aqueous media in the absence of exogenous excipients.29856606
Antimicrobial peptide N10 and NB2Both peptides were effective against A. baumannii and showed antibacterial activities (minimum inhibitory concentration (MIC) 500 micro g/ml). In the biofilm inhibition assay, NB2 reduced biofilm more efficiently (75%) than N10 (50%).The selected peptides showed significant binding to A. baumannii rather than to the human cell line Caco-2. Both peptides were effective against A. baumannii and showed antibacterial activities29859290
Marcin-18 (FFGHLFKLATKIIPSLFR), Meucin-18 (FFGHLFKLATKIIPSLFQ) and Megicin-18 (FFGALFKLATKIIPSLFR)Showed highly potent inhibitory activity against Gram-positive bacteria (MIC 1.5 to > 48.3 microM), including some clinical antibiotic-resistant strains. Importantly, in a mouse acute peritonitis model, these peptides significantly decreased the bacterial load in ascites and rescued nearly all mice heavily infected with clinical methicillin-resistant Staphylococcus aureus from lethal bacteremia.In vitro, chemically synthetic marcin-18 and its homologs (meucin-18 and megicin-18) showed highly potent inhibitory activity against Gram-positive bacteria, including some clinical antibiotic-resistant strains.29896190
Oligo-lipidated arginyl peptide (OLAP11)antimicrobial actions against MRSA infectionslow in vitro toxicityOur results showed that OLAP-11 exhibits potent antimicrobial activity against Gram-positive bacteria with improved physico-chemical activity in various physiological conditions.30066172