Antibacterial Nanocomposites

                                                                                                                                                                                                                                  Download data

Lactoferrin delivered by biomimetic hydroxyapatite nanoparticlesBetter performance of lactoferrin delivered by biomimetic hydroxyapatite nanoparticles combined with cell free supernatant from probiotic Lactobacillus paracasei compared to both lactoferrin and probiotic alone or pooled.CONCLUSION: These findings indicate the effectiveness and safety of our proposed therapy as alternative treatment for Helicobacter pylori infection.27384186
Tobramycin decorated graphene oxide AgNPs (TOB-GO-Ag)Significant loss of bacterial membrane potential from -52 +- 2 mV (control) to -2 +- 1 mV (treated) indicates a severe cell wall damage caused by TOB-GO-Ag compositeTobramycin mediated silver nanospheres/graphene oxide composite for synergistic therapy of bacterial infection.29763756
A PS (beta-carboxyphthalocyanine zinc, CPZ) delivery system with lanthanide-doped upconversion nanoparticles (UCNPs, LiYF4:Yb/Er) and polyvinylpyrrolidone (PVP)Such a near-infrared (NIR) triggered UCNPs-CPZ-PVP system significantly reduced the aggregation of CPZ and presented a high anti-infectious activity against multi-drug resistant (MDR) bacteria (methicillin-resistant Staphylococcus aureus by 4.7 log10 and MDR Escherichia coli by 2.1 log10) post aPDT (at 50 micro g mL-1 UCNPs-CPZ-PVP with 0.5 W cm-2 980 nm light).Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. An alarming worldwide increase in microbial resistance to traditional drugs and classical pharmacophores has spurred the search for new antimicrobial compounds. Antimicrobial photodynamic therapy (aPDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms.29881851
Quaternized chitosan hydrogels incorporated with NaYF4:Er/Yb/Mn@photosensitizer-doped silica (UCNPs/MB)Excellent antibacterial efficiency to both DR-S. aureus and DR-E. coli bacteriaBy incorporating UCNPs/MB-doped silica into the hydrogel, we have combined photodynamic therapy (PDT) with quaternized chitosan to obtain a high therapeutic index via a synergistic effect.26883410
Monomeric methylene blue conjugated gold nanoparticlesIn our treatment modality negligible dark toxicity suggests photochemically driven process with 97% killing of MDR bacteria.Nanoparticle-based photodynamic therapy (PDT) is increasingly been adopted as a potential antimicrobial option, yet the cytotoxicity associated with PDT is quite unspecific.28778019
Catheter loaded with silverIn vitro efficacy of a hydrophilic central venous catheter loaded with silver to prevent microbial colonization. A method was developed to load the surface of a central venous catheter with silver to prevent bacterial colonization.9532274
Tungsten nanoparticlesThe bactericidal activity of newly synthesized tungsten-nanoparticles was tested on clinical multiple drug resistant Escherichia coli isolates from UTI patients with indwelling catheters and Staphylococcus aureus reference strain. The results suggest that the particles tested in this study certainly mediate the inhibition of bacterial growth.We believe that the fabrication of W-NPs on catheters could possibly prevent them from being contaminated by pathogens and hence provide continuous protection of the site.21213591
Silver nanoparticle-doped SiO(2) microspheres (Ag-SMSs)Effective inhibition against proliferation of E. coliLarge-scale preparation of strawberry-like, AgNP-doped SiO2 microspheres using the electrospraying method. In this paper, we report on a novel strategy for the preparation of silver nanoparticle-doped SiO(2) microspheres (Ag-SMSs) with an interesting strawberry-like morphology using a simple and efficient electrospraying method.21719963
Selenium nanoparticlesStudy provided the first evidence of strongly inhibited growth of S. aureus in the presence of selenium nanoparticles after 3, 4, and 5 hours at 7.8, 15.5, and 31 ?g/mL. The percentage of live bacteria also decreased in the presence of selenium nanoparticles. Therefore, this study suggests that selenium nanoparticles may be used to effectively prevent and treat S. aureus infections and thus should be further studied for such applications.Therefore, this study suggests that selenium nanoparticles may be used to effectively prevent and treat S. aureus infections and thus should be further studied for such applications.21845045
2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan (LS-2)-loaded microparticlesActivity against Mycobacterium tuberculosis H37Rv ATCC 27294These findings are encouraging and indicate that LS-2-loaded microparticles are a potential alternative to conventional chemotherapy of TB.21854223
Chitosan (CS) nanoparticlesAnti-biofilm activity in Streptococcus mutans, Pseudomonas aeruginosa and Candida albicansChitosan nanoparticles for antimicrobial photodynamic inactivation: characterization and in vitro investigation. The growing resistance to antibiotics has rendered antimicrobial photodynamic inactivation (PDI) an attractive alternative treatment modality for infectious diseases.22283820
Titanium with chitosanThe Chitosan-coated surfaces showed strong inhibition of Actinomyces naeslundii growthFunctionalization of titanium with chitosan via silanation: evaluation of biological and mechanical performances. Complications in dentistry and orthopaedic surgery are mainly induced by peri-implant bacterial infections and current implant devices do not prevent such infections.22859940
Ag-SiO(2) NC (nano composite)Complete mortality of the bacterium was achieved with 80 ?g ml(-1) concentration of Ag-SiO(2) NC. Inside the cytoplasm, a complete inhibition of electron transport system was achieved with 100 ?g ml(-1) Ag-SiO(2) NC, followed by DNA breakage.The study thus demonstrates that Ag-SiO(2) NC invades the cytoplasm of the multiple drug-resistant P. aeruginosa by impinging upon the cell wall integrity and kills the cells by interfering with electron transport chain and the genetic stability.SIGNIFICANCE AND IMPACT OF STUDY: Although the synthesis, structural characteristics and biofunction of silver nanoparticles are well understood, their application in antimicrobial therapy is still at its infancy as only a small number of microorganisms are tested to be sensitive to nanoparticles.23083417
Silver-conjugated superparamagnetic iron oxide nanoparticles (SPION)A significant decrease in biofilm mass, which corresponds to a seven orders of magnitude decrease in viability, is observed when MRSA biofilms are treated with 1 mg/mL of silver-conjugated SPION (p greater than 0.01).For this reason, this study demonstrates for the first time that silver-conjugated SPION could be used as a targeted antibacterial therapy to the infection site.23184367
Ferrocene-carborane derivatives (FcSB1 and FcSB2) combining with nanoscaled titania (nano TiO2)FcSB1 and nano TiO2 : FIC (fractional inhibitory concentration) index values 0.375 to 0.106, FcSB2 with nano TiO2 : FIC 0.250 to 0.083NASynergistic antibacterial activity of new isomeric carborane derivatives through combination with nanoscaled titania. As a novel strategy to combat the nosocomial infection caused by multidrug-resistant (MDR) bacteria like Acinetobacter baumannii, the antibacterial effect of a pair of geometrical isomers ferrocene-carborane derivatives (designated as FcSB1 and FcSB2) combining with nanoscaled titania (nano TiO2) against five MDR A. baumannii strains were explored in this contribution.23620994
Silver nanoparticles (Ag NPs, 120 nm)Silver nanoparticles (Ag NPs, 120 nm) showed the greatest potency for reducing N. gonorrhoeae colony formation (MIC: 12.5 ?g/ml)This is the first report to screen the effectiveness of nanomaterials against N. gonorrhoeae, and our results indicate that 120 nm Ag NPs deliver low levels of toxicity to human epithelial cells and could be used as an adjuvant with antibiotic therapy, either for topical use or as a coating for biomaterials, to prevent or treat multidrug-resistant N. gonorrhoeae.23705013
Polyethyleneimine functionalized zinc oxide nanoparticlesInactivation of metronidazole-resistant Helicobacter pyloriThe molecular basis of inactivation of metronidazole-resistant Helicobacter pylori using polyethyleneimine functionalized zinc oxide nanoparticles. In view of the world wide prevalence of Helicobacter pylori infection, its potentially serious consequences, and the increasing emergence of antibiotic resistant H. pylori strains there is an urgent need for the development of alternative strategies to combat the infection.23951006
tin (Sn) doped ZnO nanostructuresSn doping enhanced the inhibitory activity of ZnO against S. aureusSn doping concentration in ZnO does not alter the cytotoxicity and ROS production, undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells.The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter.24109181
Solid lipid nanoparticles loaded with free fatty acidsA strategy was developed to target infections by producing coatings made of non-toxic chemistries lauric acid and oleic acid delivered by core-shell solid lipid nanoparticles that act against bacteria by multiple mechanisms at the nanoscale, including disruption of bacteria leading to DNA release, and reducing the adhesion of dead bacteria to ~1%. This is the first such study to explore an anti-infection surface relying on these multi-tier strategies at the nanoscale.24264141
Piperine and gentamicin nanoliposomesMIC values of gentamicin and piperine were 32 and 100 micro g/mL, respectively. Synergetic effects were observed by the combination of gentamicin and piperine and FICI was determined to be 0.5. Following incorporation of gentamicin into liposomal gentamicin and liposomal combination, the MIC values were reduced 16- and 32-fold, respectively. MBC values of gentamicin reduced 4 and 8 times following incorporation into gentamicin and combination liposomes, respectively.Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistant Staphylococcus aureus.24842547
Silver nanoparticles from P. amarus extractExhibited excellent antibacterial potential against multidrug resistant strains of P. aeruginosaCONCLUSION: The present study suggests that silver nanoparticles from P. amarus extract exhibited excellent antibacterial potential against multidrug resistant strains of P. aeruginosa from burn patients and gives insight of their potential applicability as an alternative antibacterial in the health care system to reduce the burden of multidrug resistance.25271044
poly(acrylic acid) (PAA)-coated iron oxide (magnetite) nanoparticles (PAA-MNPs)Combination of PAA-MNP and rifampicin exhibits a synergistic 4-fold-higher growth inhibition against Mycobacterium smegmatis.Polyacrylic acid-coated iron oxide nanoparticles for targeting drug resistance in mycobacteria. The emergence of drug resistance is a major problem faced in current tuberculosis (TB) therapy, representing a global health concern.25375643
Silver nanoparticles and Drosera binata extractCombination of silver nanoparticles and Drosera binata extract as a possible alternative for antibiotic treatment of burn wound infections caused by resistant Staphylococcus aureus. Staphylococcus aureus is the most common infectious agent involved in the development of skin infections that are associated with antibiotic resistance, such as burn wounds.25551660
Erythrosine nanoparticles prepared using poly-lactic-co-glycolic acid (PLGA)Significantly higher uptake and antimicrobial efficacy compared to pure drug in S. aureus cells.The introduction of photodynamic antimicrobial therapy (PAT) using erythrosine, a photosensitizer, could eliminate the bacteria without inducing antibiotic resistance or even requiring daily dosing.25629633
Silver ion doped calcium phosphate based ceramic nano-powder coated titanium nailsMicrobiological results showed that less bacterial growth was detected with the use of silver doped ceramic coated implants compared to the other two groups (p=0.003). Accumulation of silver was not detected. No cellular inflammation was observed around the silver coated prostheses. No toxic effect of silver on bone cells was seen.Silver ion doped ceramic nano-powder coated nails prevent infection in open fractures: In vivo study.26589596
ZnO-NPs and TiO2-NPsThe IC50 values of ZnO and TiO2-NPs against S. mitis ATCC 6249 were 37 and 77 micro g ml(-1), respectively, while the IC50 values against S. mitis Ora-20 isolate were 31 and 53 micro g ml(-1), respectivelyResults presented in this study verify that ZnO-NPs and TiO2-NPs can control the growth and biofilm formation activities of these strains at very low concentration and hence can be used as alternative antimicrobial agents for oral hygiene.26837748
Multi-walled carbon nanotubes (MWCNTs) covalently functionalized with immunoglobulin GUsing IgG molecules bound to MWCNTs, followed by laser irradiation, we obtained a very efficacious nanoshell-mediated laser therapy of individual MRSA agents providing highly localized killing effects for IgG-MWCNTs targeted bacteria.27301204
Silver coated single walled carbon nanotubes with antimicrobial peptides (FSWCNTs-Ag, SWCNTs-Ag-M, SWCNTs-Ag-M)The?minimum inhibitory concentration (MIC) of FSWCNTs-Ag were much lower (~7.8-3.9 micro g/ml with IC50: ~4-5 micro g/ml) compared to SWCNTs-Ag-M and plain SWCNTs-Ag (both 62.6 micro g/ml, IC50: ~31-35 micro g/ml), suggesting that the covalent conjugation of TP359 with SWCNTs-Ag was very effective on their counterpartsFSWCNTs-Ag are non-toxic to the eukaryotic cells at their MIC concentrations (5-2.5 ?g/ml) compared to SWCNTs-Ag (62.5 ?g/ml).This study described a novel approach to prepare SWCNT-Ag bio-conjugates without loss of antimicrobial activity and reduced toxicity, and this strategy will aid in the development of novel and biologically important nanomaterials.27412259
Photo-deposited silver coatings on Foley cathetersThe potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections.27612730
Silver (Ag) NPs and zinc oxide (ZnO) NPsPotent antitubercular activity at a ratio of 8ZnO/2AgNo cytotoxic effects on THP-1 cellsMixed metal oxide nanoparticles inhibit growth of Mycobacterium tuberculosis into THP-1 cells.28043541
Linear random copolymers, comprised of oligoethylene glycol (OEG), hydrophobic, and amine groups, SCPNs (single-chain polymeric nanoparticles).(SCPNs) had excellent antimicrobial activity against Pseudomonas aeruginosa at 1.4 ?M and kill ?99.99% of both planktonic cells and biofilm in one hour.Rational Design of Single-Chain Polymeric Nanoparticles That Kill Planktonic and Biofilm Bacteria. Infections caused by multidrug-resistant bacteria are on the rise and, therefore, new antimicrobial agents are required to prevent the onset of a postantibiotic era.28135798
Copper and rifampicin-loaded copper nanoparticlesActivity against Staphylococcus aureus, Escherichia coli, Bacillus pumilis and Pseudomonas fluorescensThe results obtained indicate that adsorption of rifampicin on the copper nanoparticles surface might provide the reduction of antibiotic dosage and prevent its adverse side effects.28150115
Imipenem loaded poly ?-caprolactone (PCL) and polylactide-co-glycolide (PLGA) nanocapsulesEliminated bacterial attachment and the biofilm assembly of P. aeruginosa and K. pneumoniae planktonic bacteria by 74 and 78.4%, respectively. Successfully, PCL nanocapsules were able to protect imipenem from enzymatic degradation by resistant isolates and prevent the emergence of the resistant colonies, as it lowered the mutation prevention concentration of free imipenem by twofolds.28399890
Silver and zinc oxide nanoparticlesSilver nanoparticles inhibited the growth of both A. salmonicida and A. invadans at a concentration of 17 micro g/mL. Zinc oxide nanoparticles inhibited the growth of A. salmonicida, Y. ruckeri and A. invadans at concentrations of 15.75, 31.5 and 3.15 micro g/mL respectively. In vitro assessment of the antimicrobial activity of silver and zinc oxide nanoparticles against fish pathogens28732514
Honey, polyvinyl alcohol, chitosan nanofibersComplete killing of multidrug-resistant P. aeruginosaApitherapeutics and phage-loaded nanofibers as wound dressings with enhanced wound healing and antibacterial activity. AIM: Develop green wound dressings which exhibit enhanced wound-healing ability and potent antibacterial effects.28805554
Synthesis of AgNPs and the ethyl acetate extract from Bacillus cereus A30Active against multi-drug resistant (MDR) pathogens, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosaAntibacterial efficacy of silver nanoparticles and ethyl acetate's metabolites of the potent halophilic (marine) bacterium, Bacillus cereus A30 on multidrug resistant bacteria. Bacteria are generally responsible for the prevalence of several diseases and pathogenic bacteria are showing increasing resistance to different antibacterials.29072532
Trimetal (CuZnFe) oxide nanoparticles (NPs)the antibacterial activity of the trimetal oxide NPs was greater against E. coli than against E. faecalis.However, the cytotoxicity of trimetal NPs to mammalian cells needs to be verified.Conclusion: The combination of three metal oxide NPs (ZnO, CuO, and Fe2O3) in one multimetal (CuZnFe) oxide NPs will enhance the therapeutic strategy against a wide range of microbial infections.29317817
Azole complexes combined with AgNPsThe use of azole complexes combined with AgNPs provides a new alternative against bacterial infections, especially when current treatments are associated with the rapid development of antibiotic resistance.29419803
Apigenin-mediated AgNPs (Silver Nanoparticles)Efficacy against Prevotella melaninogenica and Arcanobacterium pyogenesToxic effect of cell death was caused by an increase in oxidative stressTherefore, the biomolecule (apigenin)-mediated synthesis of AgNPs shows potential as an alternative antimicrobial therapy for bovine metritis and endometritis.29659523
ZnO-NPActivity against Acinetobacter baumanniiThese results demonstrate that ZnO-NP could be developed as alternative therapeutics against A. baumannii.29928271
Bioactive Glass (BG) incorporating silver (BgAg)Active ggainst Pseudomonas aeruginosa and Staphylococcus aureusTaken together, the findings provide evidence that BgAg elicits potent antimicrobial effects against planktonic and single-species biofilms, with beneficial effects on the host tissue response.30018606
NH2-FF-COOH nanotubes structurepotent activity against staphylococcal biofilms, resulting in complete kill at concentrations of 10 mg/mL.Self-assembling diphenylalanine peptide nanotubes selectively eradicate bacterial biofilm infection30031161
Mercaptopyrimidine conjugated Au NCHave combined mechanism including cell membrane destruction, DNA damage, and reactive oxygen species (ROS) generationHerein, we demonstrate that a novel class of Au NCs, mercaptopyrimidine conjugated Au NCs, can act as potent nanoantibiotics targeting these intractable superbugs in vitro and in vivo, without induction of bacterial antibiotic resistance and noticeable cytotoxicity to mammalian cells.30063328
Biologically synthesized silver nanoparticles (bio-AgNP), produced by Fusarium oxysporum, and oregano (Origanum vulgare) essential oil OEOActivity against multidrug-resistant bacteria, such as MRSA, and ?-lactamase- and carbapenemase-producing Escherichia coli and Acinetobacter baumannii strains with MIC ranging from 0.298 to 1.193 mg/mL and 62.5 to 250 micro MStudies have shown that oregano (Origanum vulgare) essential oil (OEO) and silver nanoparticles have potent antibacterial activity, also against multidrug-resistant strains; however, the strong organoleptic characteristics of OEO and the development of resistance to these metal nanoparticles can limit their use.27242772
Cardamom oil loaded chitosan nano-particlesAnti-microbial potential against extended spectrum ? lactamase producing Escherichia coli and methicillin resistant Staphylococcus aureusEncapsulation of Cardamom Essential Oil in Chitosan Nano-composites: In-vitro Efficacy on Antibiotic-Resistant Bacterial Pathogens and Cytotoxicity Studies.27757108
Silver nanoparticles and visible blue lightActivity against methicillin-resistant Staphylococcus aureusA combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). 27530257