Antifungal Photodynamic Therapy

                                                                                                                                                                                                                                  Download data

Cu-sputtered polyester surfaces (Cu-PES) and low intensity visible light irradiation (4.65mW/cm2)Cu-PES exhibited an accelerated fungicidal activity against Candida albicans and Candida glabrata with a reduction of 3.0 and 3.4log10CFU These results indicate that Cu-PES represent a promising strategy for decreasing the colonization of surfaces by yeasts and that actinic light can improve its self-disinfecting activity. 28802173
a PS (beta-carboxyphthalocyanine zinc, CPZ) delivery system with lanthanide-doped upconversion nanoparticles (UCNPs, LiYF4:Yb/Er) and polyvinylpyrrolidone (PVP)Such a near-infrared (NIR) triggered UCNPs-CPZ-PVP system significantly reduced the aggregation of CPZ and presented a high anti-infectious activity against multi-drug resistant (MDR) bacteria (methicillin-resistant Staphylococcus aureus by 4.7 log10 and MDR Escherichia coli by 2.1 log10) post aPDT (at 50 micro g mL-1 UCNPs-CPZ-PVP with 0.5 W cm-2 980 nm light). Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. An alarming worldwide increase in microbial resistance to traditional drugs and classical pharmacophores has spurred the search for new antimicrobial compounds. Antimicrobial photodynamic therapy (aPDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms.29881851
Curcumin and blue lightEradication of C. albicans biofilms Photodynamic therapy (PDT) utilizing curcumin and blue light was tested as an independent therapy and in combination with fluconazole treatment.29364155
Fluorescent probes hydroxyphenyl fluorescein (HPF) and aminophenyl fluorescein (APF) after toluidine blue (TBO-37.5 mg/L)-mediated PDT (660 nm, 40 mW, and 0.04 cm2?spot area)Significant generation of hydroxyl radicals and hypochlorite after TBO-PDT with doses around 90 J/cm2; for inactivating Paracoccidioides brasiliensis colonies at 7 and 15 days In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions.28349345
Methylene blue-mediated photodynamic therapyConcentrations from 250 to 400 microgram/mL reduced fungal growth but did not eliminate Candida albicans.: MB concentrations of 450 and 500 microgram/mL totally eradicated Candida albicans from the oral cavity, resulting in reductions from 2.5 log(10) and 2.74 log(10) to 0, respectively Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model. OBJECTIVES: The purpose of this study was to evaluate the efficacy of using methylene blue (MB)-mediated photodynamic therapy to treat oral candidiasis in an immunosuppressed murine model, mimicking what is found in human patients.11862203
New methylene blue N and red lightEffect on Candida albicans proteome Here, we report a combination of two-dimensional electrophoresis and tandem mass spectrometry to study the protein damage resulting from treating C. albicans with PDT with new methylene blue N and red light.27830217
PDT method based on light curing units' blue LEDs combined to a plaque-disclosing composition (5% erythrosine)Can inactivate C. albicansPreclinical study of a cost-effective photodynamic therapy protocol for treating oral candidoses. Photodynamic therapy (PDT) is a promising treatment for oral candidoses.28508242
PSs hypericin (HYP) and 1,9-dimethyl methylene blue (DMMB) exposed to two light-emitting diode light fluences (18 and 37 J cm??)The minimal fungicidal concentration of HYP for greater than 3 log?? CFU reduction (0.5 McFarland) was 0.62 micromol l?? for most strains, whereas for DMMB it ranged between 1.25 and 2.5 micromol/L Photodynamic fungicidal efficacy of hypericin and dimethyl methylene blue against azole-resistant Candida albicans strains. Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to treat infections based on the use of photosensitisers (PSs) and visible light.23905682
Riboflavin/UVA combination (365 nm) combination Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. PURPOSE: To demonstrate the antimicrobial properties of riboflavin/UVA (365 nm) against common pathogens.18408193