Antifungal Photodynamic Therapy

                                                                                                                                                                                                                                  Download data

Cu-sputtered polyester surfaces (Cu-PES) and low intensity visible light irradiation (4.65mW/cm2)Cu-PES exhibited an accelerated fungicidal activity against Candida albicans and Candida glabrata with a reduction of 3.0 and 3.4log10CFU These results indicate that Cu-PES represent a promising strategy for decreasing the colonization of surfaces by yeasts and that actinic light can improve its self-disinfecting activity. 28802173
a PS (beta-carboxyphthalocyanine zinc, CPZ) delivery system with lanthanide-doped upconversion nanoparticles (UCNPs, LiYF4:Yb/Er) and polyvinylpyrrolidone (PVP)High antifungal efficacy against Candida albicans Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles. An alarming worldwide increase in microbial resistance to traditional drugs and classical pharmacophores has spurred the search for new antimicrobial compounds. Antimicrobial photodynamic therapy (aPDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms.29881851
Curcumin and blue lightEradication of C. albicans biofilms Photodynamic therapy (PDT) utilizing curcumin and blue light was tested as an independent therapy and in combination with fluconazole treatment.29364155
Fluorescent probes hydroxyphenyl fluorescein (HPF) and aminophenyl fluorescein (APF) after toluidine blue (TBO-37.5 mg/L)-mediated PDT (660 nm, 40 mW, and 0.04 cm2?spot area)Significant generation of hydroxyl radicals and hypochlorite after TBO-PDT with doses around 90 J/cm2; for inactivating Paracoccidioides brasiliensis colonies at 7 and 15 days In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions.28349345
Methylene blue-mediated photodynamic therapyConcentrations from 250 to 400 microgram/mL reduced fungal growth but did not eliminate Candida albicans.: MB concentrations of 450 and 500 microgram/mL totally eradicated Candida albicans from the oral cavity, resulting in reductions from 2.5 log(10) and 2.74 log(10) to 0, respectively Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model. OBJECTIVES: The purpose of this study was to evaluate the efficacy of using methylene blue (MB)-mediated photodynamic therapy to treat oral candidiasis in an immunosuppressed murine model, mimicking what is found in human patients.11862203
New methylene blue N and red lightEffect on Candida albicans proteome Here, we report a combination of two-dimensional electrophoresis and tandem mass spectrometry to study the protein damage resulting from treating C. albicans with PDT with new methylene blue N and red light.27830217
PDT method based on light curing units' blue LEDs combined to a plaque-disclosing composition (5% erythrosine)Can inactivate C. albicansPreclinical study of a cost-effective photodynamic therapy protocol for treating oral candidoses. Photodynamic therapy (PDT) is a promising treatment for oral candidoses.28508242
PSs hypericin (HYP) and 1,9-dimethyl methylene blue (DMMB) exposed to two light-emitting diode light fluences (18 and 37 J cm??)The minimal fungicidal concentration of HYP for greater than 3 log?? CFU reduction (0.5 McFarland) was 0.62 micromol l?? for most strains, whereas for DMMB it ranged between 1.25 and 2.5 micromol/L Photodynamic fungicidal efficacy of hypericin and dimethyl methylene blue against azole-resistant Candida albicans strains. Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to treat infections based on the use of photosensitisers (PSs) and visible light.23905682
Riboflavin/UVA combination (365 nm) combination Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. PURPOSE: To demonstrate the antimicrobial properties of riboflavin/UVA (365 nm) against common pathogens.18408193
Aloe emodin (AE)AE exhibited no significant dark toxicity, but in the presence of light, effectively inactivated C. albicans cells in a concentration-dependent manner.32232258
Tagetes minutaTagetes minuta extracts as a photosensitizer on growth of Candida and dermatophytes and their effect on Candida virulence factors. T. minuta root hexane and dichloromethane extracts demonstrated high photodynamic antifungal activity.Photodynamic therapy (PDT) involves the topical administration of a photosensitizer in combination with light of an appropriate wavelength and molecular oxygen that produces reactive oxygen species (ROS), which promote damage to several vital components of the microorganism.31724710
5-aminolevulinic acid PDT (ALA-PDT)Using combination therapy, we have successfully treated a patient who had a T. asahii skin infection. Further in vitro studies showed that the antifungal effect of ALA-PDT on planktonic and adherent T. asahii was dependent on the concentration of ALA and light dosages used.Photodynamic therapy (PDT) is a new therapeutic approach developed not only to combat cancerous lesions but also to treat infectious diseases such as fungal infections.33164224
Hypocrellin B (HB)Inactivated the azole-sensitive and resistant C. albicans in a light-dose and PS concentration-dependent manner.HB exhibited no significant dark toxicityAntimicrobial photodynamic therapy (aPDT) is an emerging and promising approach for treating localized and superficial C. albicans infections.31325521
5-aminolevulinic acid (5%ALA) in a thermosetting gel (t) (5%ALA-PTt)The 5% ALA-PTt preparation was shown to be effective in reducing the growth of biofilm and inoculum of C. albicans.Newly formulated 5% 5-aminolevulinic acid photodynamic therapy on Candida albicans.31614222
Photodynamic activity of hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH) extracts from T. pentachaeta var. belenidiumMIC = 8-256 microgram/mL, synergistic effects with ciprofloxacin and fluconazoleTaking together, results demonstrated the strong photodynamic effects of T. pentachaeta root extracts under UVA irradiation, making them valuable alternatives to the already established antifungal drugs against C. albicans.34148723
Methylene blue (MB)-PDTMICs ?0.004-4 mg/L against Trichophyton species, MIC elevated (MB: 2-8 mg/L and 8-16 mg/L) in isolates from two pigmented cultures of Trichophyton interdigitale (one wildtype and one harbouring L393F) with a darker color when compared to unpigmented cultures (MB: 0.5-4 mg/L)Photodynamic therapy: A treatment option for terbinafine resistant Trichophyton species.33497815
Phenothiazinium photosensitizers, methylene blue, new methylene blue N and the pentacyclic S137 and light-emitting diodes with an emission peak at 635 nm and an integrated irradiance from 570 to 670 nm of 9.8 mW cm-2The results from this model indicate that antimicrobial photodynamic therapy with methylene blue, new methylene blue N and S137 is efficient for the treatment of infection with Fusarium keratoplasticum and Fusarium moniliformeAntimicrobial photodynamic therapy with phenothiazinium photosensitizers in non-vertebrate model Galleria mellonella infected with Fusarium keratoplasticum and Fusarium moniliforme.30586617
Aminolevulinic acid mediated-antimicrobial photodynamic therapy (ALA aPDT)using narrow band LED (633 ? 10 nm) at the light intensity of 100 mW/cm2 and at a distance of 1 cm for 900 sOur study shows ALA aPDT induced 46% ? 24.23% reduction of the growth of all tested P. wickerhamii strains in T1 group. ALA aPDT induced 50.39% ? 19.88% reduction of the growth of all tested P. wickerhamii strains in T2 group. ALA aPDT induced 52.68 ? 20.22% reduction of the growth of all tested P. wickerhamii strains inT3 group. Single ALA aPDT induced 32.97% ? 1.6% growith reduction of three tested strains(O23d, O23e and 62,207), while repeated ALA aPDT induced 51.65 ? 2.91% reduction of the growth(P value = 0.000).?ALA aPDT can inactivate the growth of P. wickerhamii, and repeated aPDT has more photoinactivation of P. wickerhamii30586618
Photodynamic inactivation (PDI) mediated by hypericin encapsulated in P-123 copolymeric micelles (P123-Hyp) alone and in combination with fluconazole (FLU)Most of isolates (70%) were completely inhibited with concentrations up to 2.0 micro mol/l of HYP and light fluence of 16.2 J/cm2. FLU-resistant strains had synergic effect with P123-HYP-PDI and FLU.P123-Hyp-PDI is a promising option to treat fungal infections and medical devices to prevent biofilm formation and fungal spread.31033353