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Antiparasitic Phytochemicals and Natural Products

                                                                                                                                                                                                                                  Download data

ENTITY POTENCY SAFETY INFORMATION EVIDENCE PMID
Hydroalcoholic extract of the leaves of Ziziphus joazeiro Mart. (HELZJ)IC50 was 612.06 micro g/ mL against T. cruzi, and for the protozoans L. braziliensis and L. infantum, IC50 values were greater than 5000 and 693.67 micro g/mL, respectivelyLow toxicity in fibroblasts in vitroThus, our results indicate that Z. joazeiro Mart. (HELZJ) could be a source of plant-derived natural products that could lead to the development of promising new antibiotic compounds for infectious diseases.25976809
Petroleum ether, chloroform, ethyl acetate, methanol and aqueous extracts from the roots of T. erecta and a new bithienyl compound, 2-hydroxymethyl-non-3-ynoic acid 2-[2,2']-bithiophenyl-5-ethyl ester from the roots of the plantEthyl acetate fraction exhibited IC(50) of 0.02 and 0.07 mg/mL against the chloroquine sensitive and resistant strains of Plasmodium falciparum respectively, the new bithienyl compound also showed significant schizonticidal activity against both chloroquine sensitive and resistant strains of Plasmodium falciparum with the IC(50) values of 0.01 and 0.02 mg/mLFive successive extracts (petroleum ether, chloroform, ethyl acetate, methanol and aqueous) of the roots of T. erecta and a new bithienyl compound, 2-hydroxymethyl-non-3-ynoic acid 2-[2,2']-bithiophenyl-5-ethyl ester from the roots of the plant, were evaluated for in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum.20818936
Kenyan medicinal plants (Toddalia asiatica (root bark), Rhamnus prinoides (leaves and root bark), Vernonia lasiopus (root bark), root bark and/or leaf extracts of Maytenus acuminata, M. heterophylla, M. senegalensis, Rhamnus staddo and Withania somnifera (root bark))Toddalia asiatica (root bark), Rhamnus prinoides (leaves and root bark) and Vernonia lasiopus (root bark) showed high chemosuppression in the range 51%-75%, activity of V. lasiopus (all parts), leaf extracts of M. senegalensis, R. prinoides and T. asiatica as well as root barks of M. heterophylla, R. staddo and T. asiatica enhabced in combination with chloroquineIn Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice17221829
CurcuminHigher than 95% inhibition of Cryptosporidium parvum growth at 50 microM for 24 hAltogether curcumin showed promising anticryptosporidial effects under in vitro conditions and deserves further exploration.19557435
Ethanolic extract of P. longifolia (Sonn) Thw. var. pendula stem bark (clerodane diterpenes [16-hydroxycleroda-3,13-dien-16,15-olide (1), 16-oxocleroda-3,13E-dien-15-oic acid (2) and 3,16-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (3)], a steroid [beta-stigmasterol (4)] and two alkaloids [darienine (5) and stepholidine (6)])The clerodane diterpenes exhibited significantly potent (p<0.005) blood schizonticidal activity (IC50: 3-6 micro g/ml),?while compounds 4, 5 and 6 exhibited weak antiplasmodial activity (IC50 22-105 micro g/ml)The potent antiplasmodial activity of the extract of P. longifolia (Sonn) Thw. var. pendula and compounds therein strongly suggests its usefulness as an antimalarial agent and supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.25914039
Triterpenoids (Piperazine derivatived from betulinic acid)Minimum inhibitory concentration (MIC) value of 91.2 microM against Trichomonas vaginalisThis is the first report of semisynthetic triterpenoid derivatives with anti-T. Vaginalis activity, revealing the high potential of these compounds as trichomonacidal agents.24880238
Compounds from MEDINA microbial products collectionActivity against Plasmodium falciparum?A subset of more than 20,000 extracts from the MEDINA microbial products collection has been explored, leading to the discovery of 3 new compounds with antimalarial activity26735308
Sapindus saponinsy, the MIC of Sapindus saponins for T. vaginalis (0.005%) was found to be 10-fold lower than its effective spermicidal concentration (0.05%)Findings demonstrate the potential of Sapindus saponins for development as a microbicidal contraceptive for human use.18544604