Antiviral Phytochemicals and Natural Products

                                                                                                                                                                                                                                  Download data

S. chinensis fruit lignans, Schisandrin B and DeoxyschizandrinHIV-1 inhibitorFrom the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors. We purified 6 lignans from Schisandra chinensis fruits and assayed their effects on HIV-1 RT and viral replication. Among the S. chinensis fruit lignans, Schisandrin B and Deoxyschizandrin selectively inhibited the HIV-1 RT-associated DNA polymerase activity25740376
Pomegranate rind extract and punicalagin coadministered zinc (II)Herpes simplex virus (HSV)Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV. BACKGROUND: There is a clinical need for new therapeutic products against Herpes simplex virus (HSV).28665969
Licochalcone G (1) and seven known (2-8) chalconesActivity influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y)Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. During our course of an anti-influenza screening program on natural products, one new licochalcone G (1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata.21123068
Calanolides A (1) and B (4)Against HIV-1The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. Eight new coumarin compounds (1-8) were isolated by anti-HIV bioassay-guided fractionation of an extract of Calophyllum lanigerum.1379639
LADANIA067 from the leaves of the wild black currant (Ribes nigrum folium)Anti influenza A viruses (IAV)A plant extract of Ribes nigrum folium possesses anti-influenza virus activity in vitro and in vivo by preventing virus entry to host cells. In conclusion, an extract from the leaves of the wild black currant might be a promising source for the development of new antiviral compounds to fight IAV infections.23717460
N-acetylglucosamine-binding protein from Urtica dioica (UDA)Prevents HIV entryCarbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV. Mannose-binding proteins derived from several plants (i.e.16183648
Cajanine derivatives Cajanus cajan L.Cajanine was identified as a potent HCV inhibitor with EC50?= 3.17 ? 0.75 microMDesign and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1. There still remains a need to develop new anti-HCV agents with distinct mechanism of action (MOA) due to the occurrence of resistance to direct-acting antiviral agents (DAAs).27783522
Melissa extractFree viral particles of two acyclovir-resistant HSV strains at low IC50 values of 0.13 and 0.23 microg/mLMelissa extract exhibits low toxicity and affects attachment and penetration of acyclovir-sensitive and acyclovir-resistant HSVs in vitro.Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract. Medicinal plants are increasingly of interest as novel source of drugs for antiherpetic agents, because herpes simplex virus (HSV) might develop resistance to commonly used antiviral drugs.24817544
Nordihydroguaiaretic acid (6)HIV-1 Nucleocapsid Protein InhibitorsStructure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains. Here, using a multidisciplinary approach combining in silico screening, fluorescence-based molecular assays, and cellular antiviral assays, we identified nordihydroguaiaretic acid (6), as a novel natural product inhibitor of NC.29235845
Cistus incanus (Ci) extractsCi extracts show potent and broad in vitro antiviral activity against viruses that cause life-threatening diseases in humans and are promising sources of agents that target virus particles.Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. These results demonstrate that Ci extracts show potent and broad in vitro antiviral activity against viruses that cause life-threatening diseases in humans and are promising sources of agents that target virus particles.26833261
Brazilian flora [natural alkaloid isolated from Maytrenus ilicifolia, and the lignans from Peperomia blanda]The compounds APS (EC50=2.3microM), a natural alkaloid isolated from Maytrenus ilicifolia, and the lignans 3(?)43 (EC50=4.0microM), 3(?)20 (EC50=8.2microM) and 5(?)362 (EC50=38.9microM) from Peperomia blanda dramatically inhibited HCV replication as judged by reductions in luciferase activity and HCV protein expression in both the subgenomic and infectious systems.Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro.25557602
Chinese medicinal formula LiangchaChinese medicinal formula Liangcha, inhibition rate more than 50% at the concentration of 5.3 microg/ was not significantly cytotoxic in several T lymphocytes cell lines with CC50 range 564.79 - 1699.22 microg/mL.RESULTS: The extracts from Chinese medicinal formula Liangcha exhibited potent and broad-spectrum anti-HIV-1 activity on different HIV-1 strains with EC50 range 12.74 -116.87 microg/mL, but weakly inhibited HIV-2 replication.21243774
MeOH extract of Symphyocladia latiuscula2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (TDB) of a CH(2)Cl(2)-soluble fraction was active against wild type HSV-1, as well as AP(r) HSV-1 and TK(-) HSV-1 (IC(50) values of 5.48, 4.81 and 23.3 microg/ml, respectively)Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice16327161
Acacia catechu extractsThe aqueous and 50% ethanolic extracts of A. catechu showed IC50 values of 1.8 ? 0.18 ?g/ml and 3.6 ? 0.31 ?g/ml, respectively in cell-free virus based assay using TZM-bl cells and HIV-1NL4.3 (X-4 tropic), The n-butanol fraction demonstrates a potent inhibitory activity against the viral protease (IC50 = 12.9 microg/ml), but not reverse transcriptase or integrase.Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat25228267
Polyphenol rich extract (CYSTUS052) from the Mediterranean plant Cistus incanusEffective dose of 50 microg/mlHere we demonstrate that a polyphenol rich extract (CYSTUS052) from the Mediterranean plant Cistus incanus exerts a potent anti-influenza virus activity in A549 or MDCK cell cultures infected with prototype avian and human influenza strains of different subtypes.17572513
Micrococcin P1Inhibiting HCV entry with an EC50 range of 0.1-0.5 microM.Accordingly, our study aimed to identify affordable novel HCV inhibitors by screening of natural product compound libraries.27387825
Phyllanthus extractInhibited HBV DNA synthesisInhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro. These data indicate that Phyllanthus extract may be useful as an alternative therapeutic agent for the treatment of drug-resistant CHB patients.26220282