Antifungal Nanocomposites

                                                                                                                                                                                                                                  Download data

Amphotericin B-conjugated silver nanoparticlesBiogenic silver nanoparticles revealed low to moderate antifungal activity (4-8 mm +- 0.2), however, the amphotericin B conjugated silver nanoparticles exhibited significant activity against Candida albicans (16 mm +- 1.4) and Candida tropicalis (18 mm +- 1.5)Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections. 27591110
Chitosan silver nanocomposite (CAgNC)Activity of chitosan silver nanocomposite (CAgNC) was tested against C. albicans Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of CAgNC were determined as 25 and 100 microg/ml, respectively Overall results from our study indicated that CAgNC could affect negatively on physiological and biochemical functions of C. albicans suggesting CAgNC as a potential alternative for antifungal chemotherapy. 27495320
Fluconazole-loaded solid lipid nanoparticles (FLZ-SLNs) The MIC50 drug concentrations were 2microg/ml, 1microg/ml and 2microg/ml for FLZ-resistant strains of Candida albicans, Candida parapsilosis and Candida glabrata, respectivelyTime to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. 26974361
NB-002, a novel nanoemulsionFor filamentous nondermatophyte fungi, the MIC range varied from 0.06 to 0.5 microg/ml for Alternaria spp. to 2 to 8 microg/ml for Paecilomyes spp.: NB-002 had activity against both azole-susceptible and -resistant Candida albicans yeast isolates, with MIC(90)s of 2 microg/ml, respectively, and minimum fungicidal concentrations at which 90% of isolates are inhibited of 4 and 8 microg/ml, respectively.: NB-002 killed both mycelia and microconidia even when the fungal forms were dormant or not actively growing. NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. NB-002 is an oil-in-water emulsion designed for use for the treatment of skin, hair, and nail infections.19433562
Polyvinylpyrrolidone-Coated Silver Nanoparticles and Azole AntifungalEffective in being against the drug-resistant C. albicans Synergy Between Polyvinylpyrrolidone-Coated Silver Nanoparticles and Azole Antifungal Against Drug-Resistant Candida albicans. Our results suggest that the combinational use of engineered nanomaterials (ENMs), such as PVP-coated Ag-NPs, with the conventional antifungal may be a viable strategy to combat drug-resistant fungal infection. 27455637
Silver nanoparticles (AgNPs)MIC50 were 0.1 micro g ml(-1) and MFC were 0.25 and 0.5 microg ml(-1) for C. glabrata and C. krusei, respectively In vitro antifungal activity of silver nanoparticles against fluconazole-resistant Candida species. Nowadays, current advances in nanotechnology constitute a promising alternative in the development of new antimicrobial agents.26335058
Tea tree oil nanoemulsionsStrong in vitro antimicrobial activities on Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans Taken together, our results show that the inhalable nanoTTOs are promising nanomedicines for local therapies of fungal and bacterial pneumonia with no obvious adverse events.26895502
Zinc Oxide (ZnO) nanoparticles and EDTAEffective antifungal properties at the concentration of 5.2, 8.6 microg/ml for Fluconazole susceptible strain and 5.42, 10.8 microg/ml Fluconazole resistant strains of C. tropicalis biofilms CONCLUSION: In present study we conclude, ZnO considered as a new agent in field of prevention C. tropicalis biofilms especially biofilms formed surface of medical device. 27653145
Arginine-phenylalanine and arginine-tryptophan-based surfactantsAntifungal activity against fluconazole-resistant Candida spp. strains, with a low minimum inhibitory concentration (8.2 microgramg/mL)Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds.34391169
Ag/BN NPsThe Ag/BN nanohybrids and amphotericin B-loaded BN and Ag/BN NPs also reveal high fungicidal activity against C. albicans, C. auris, C. parapsilosis, and N. crassa cells.Herein, we demonstrate that Ag/BN NPs and antibiotic-loaded BN and Ag/BN nanoconjugates are promising carriers to fight bacterial and fungal infections34000197
ultra-small silver nanoclusters (rsAg/NCs)we also established that the apoptosis-inducing potential of rsAg/NCs is due to the activation of Ras signaling, which confirms their application in combating FCZ-resistant C. albicans infections.Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated.30769763
Green synthesis of silver nanoparticles by Conocarpus Lancifolius plant extractsignificant activity against fungal pathogen Rhizopusus stolonifera and Aspergillus flavusBased on our results, biogenic AgNPs reveal significant activity against fungal pathogen Rhizopusus stolonifera and Aspergillus flavus that cause leading infectious diseases.35002442
Synergistic Antimicrobial Metal Oxide-Doped Phosphate Glassesfungal strain (Candida albicans)An enhanced antimicrobial effect, at 5 mg/mL concentration, was exhibited by cobalt, copper, and zinc oxide glasses alone and in combinations.35199992
Short Guanidinium-Functionalized Poly(2-oxazoline)sDisplaying Potent Therapeutic Efficacy on Drug-Resistant Fungal InfectionsThe easy synthesis and structural diversity of POXs imply their potential as a class of promising antifungal agents.35182092
chemically and biologically synthesized silver nanoparticlesagainst three fungal strains (Aspergillus flavus, Fusarium moniliforme, and Candida albicans, all isolated from Nile tilapia)35280558
poly(methacrylic acid)-silver nanoparticles (PMAA-AgNPs)against fluconazole-resistant Candida albicans strainsConclusions: This study demonstrated that, in general, PMAA-AgNPs acts synergistically in combination with fluconazole, inhibiting fluconazole-resistant C. albicans strains. PMAA-AgNPs-fluconazole combination was also able to inhibit germ tube formation, an important virulence factor. Inhibitory effect of PMAA-AgNPs alone or in combination was higher in C. albicans than in mammalian cells.35338561
polyacrylonitrile (PAN) nanofibers coated with silver nanoparticles (AgNPs) and silver(I,III) oxide.different concentrations of AgNO3 (0, 5, 10, and 15% wt % w.r.t to weight of PAN) were used. results also indicate that PAN-AgNP nanocomposites possess relatively less antimicrobial activity against Gram-negative bacteria compared to Gram-positive bacteria and C. albicans.Our study demonstrates that PAN-AgNP nanocomposites, a novel polymer material with long-term universal antimicrobial stability, can potentially be applied as a universal antimicrobial. data also indicate that PAN-AgNP nanocomposites synthesized from higher wt % concentrations of AgNO3 demonstrated more antimicrobial efficiency against all 10 microbes compared to samples synthesized from lower concentrations of metal salts.36591150
polypropargyl alcohol nanoparticles (nano-PGA)Nano-PGA-DMF (dimethylformamide) exhibits significant antimicrobial potential against Candida albicans (C.albicans) (12.50 mm; ZOI, and 1.87 microg/mL; MIC).It was found that the nano-PGA polymer prepared in DMF has better antimicrobial activity than one prepared in chloroform than in water.36152795
Chrysophyllum albidum fruit peels to prepare silver nanoparticles (Alb-AgNPs).The antimicrobial properties of the Alb-AgNPs were studied with selected microorganisms namely; S. aureus, E. coli, K. pneumoniae, B. subtilis, S. mutans, P. aeruginosa, S. typhi, and Candida albicans. High inhibitory activity against the microorganisms were exhibited with MICs ranging from 15.62 to 1000 microg/mL. the Alb-AgNPs could serve as a biofilm inhibitor with the highest percent inhibition of about 92% against methicillin-resistant Staphylococcus aureusThe results from this study thus provide access to the simple, sustainable, economic and eco-friendly synthesis of silver nanoparticles with efficient antimicrobial properties as drug candidates as a means of overcoming the prevailing antibiotic resistance menaces.36586061
silver nanoparticles (AgNPs) from Withania somnifera and Fagonia indicaSilver nanoparticles of F. indica exhibited the highest significant activity against Aspergillus flavus and Fusarium oxysporum while AgNPs of W. somnifera were active only against A. flavus. The highest significant inhibition was obtained for crude extract (46.7) and AgNPs (45.7) of F. indica at 1000 microg/ml.Both crude and AgNPs showed potent activity; however, in comparison, silver nanoparticles showed slightly enhanced activity. Crude and AgNPs of both plants showed good phytotoxic and insecticidal inhibition. Antimicrobial studies of AgNPs on diseases causing pathogens open a door for new antimicrobial agents and could be the answer to antibiotic resistance after further analysis.36440367
anti-biotic drug metronidazole loaded ZIF-90 nanoparticlesIn anti-fungal activity, studies show excellent growth inhibition against human pathogenic fungi Aspergillus fumigatus and Candida albicansthe fabricated MI@ZIF-90 drug delivery system is non-toxic to biomedical applicationsThe overall research findings highlight the design of a smart drug delivery system for sepsis treatment. In future it will be an efficient, low-cost, and biocompatible pharmaceutics for pediatric sepsis management processes.36509311
gold nanoparticles (AuNP)effects on the architecture of Candida tropicalis biofilms.The fungicidal activity and cellular stress of both AuNPs affected biofilm growth through accumulation of reactive oxygen species and reactive nitrogen intermediates. However, cetyltrimethylammonium bromide-stabilized AuNPs revealed a higher redox imbalance. We correlated, for the first time, AuNP effects with the redox imbalance and alterations in the architecture of C. tropicalis biofilms.36515357
Trigonella incise (Linn) Mediated Biosynthesized Silver Nanoparticlesthe nanoparticles showed more significant antimicrobial activity against Salmonella typhi (S. typhi) and Staphylococcus aureus (S. aureus) with an inhibition zone of 21.5 mm and 20.5 mm at 6 microg/mL concentrations, respectively. The best antifungal activity was observed by synthesized Ag NPs against Candida albicans (C. albicans) with 21 mm zone of inhibition, as compared to a standard drug which gives 22 mm of inhibition.we conclude that the antibacterial and antifungal activities showed satisfactory results from the synthesized Ag NPs.35889490