Antifungal Nanocomposites

                                                                                                                                                                                                                                  Download data

Amphotericin B-conjugated silver nanoparticlesBiogenic silver nanoparticles revealed low to moderate antifungal activity (4-8 mm +- 0.2), however, the amphotericin B conjugated silver nanoparticles exhibited significant activity against Candida albicans (16 mm +- 1.4) and Candida tropicalis (18 mm +- 1.5)Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections. 27591110
Chitosan silver nanocomposite (CAgNC)Activity of chitosan silver nanocomposite (CAgNC) was tested against C. albicans Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of CAgNC were determined as 25 and 100 microg/ml, respectively Overall results from our study indicated that CAgNC could affect negatively on physiological and biochemical functions of C. albicans suggesting CAgNC as a potential alternative for antifungal chemotherapy. 27495320
Fluconazole-loaded solid lipid nanoparticles (FLZ-SLNs) The MIC50 drug concentrations were 2microg/ml, 1microg/ml and 2microg/ml for FLZ-resistant strains of Candida albicans, Candida parapsilosis and Candida glabrata, respectivelyTime to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. 26974361
NB-002, a novel nanoemulsionFor filamentous nondermatophyte fungi, the MIC range varied from 0.06 to 0.5 microg/ml for Alternaria spp. to 2 to 8 microg/ml for Paecilomyes spp.: NB-002 had activity against both azole-susceptible and -resistant Candida albicans yeast isolates, with MIC(90)s of 2 microg/ml, respectively, and minimum fungicidal concentrations at which 90% of isolates are inhibited of 4 and 8 microg/ml, respectively.: NB-002 killed both mycelia and microconidia even when the fungal forms were dormant or not actively growing. NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. NB-002 is an oil-in-water emulsion designed for use for the treatment of skin, hair, and nail infections.19433562
Polyvinylpyrrolidone-Coated Silver Nanoparticles and Azole AntifungalEffective in being against the drug-resistant C. albicans Synergy Between Polyvinylpyrrolidone-Coated Silver Nanoparticles and Azole Antifungal Against Drug-Resistant Candida albicans. Our results suggest that the combinational use of engineered nanomaterials (ENMs), such as PVP-coated Ag-NPs, with the conventional antifungal may be a viable strategy to combat drug-resistant fungal infection. 27455637
Silver nanoparticles (AgNPs)MIC50 were 0.1 micro g ml(-1) and MFC were 0.25 and 0.5 microg ml(-1) for C. glabrata and C. krusei, respectively In vitro antifungal activity of silver nanoparticles against fluconazole-resistant Candida species. Nowadays, current advances in nanotechnology constitute a promising alternative in the development of new antimicrobial agents.26335058
Tea tree oil nanoemulsionsStrong in vitro antimicrobial activities on Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans Taken together, our results show that the inhalable nanoTTOs are promising nanomedicines for local therapies of fungal and bacterial pneumonia with no obvious adverse events.26895502
Zinc Oxide (ZnO) nanoparticles and EDTAEffective antifungal properties at the concentration of 5.2, 8.6 microg/ml for Fluconazole susceptible strain and 5.42, 10.8 microg/ml Fluconazole resistant strains of C. tropicalis biofilms CONCLUSION: In present study we conclude, ZnO considered as a new agent in field of prevention C. tropicalis biofilms especially biofilms formed surface of medical device. 27653145
Arginine-phenylalanine and arginine-tryptophan-based surfactantsAntifungal activity against fluconazole-resistant Candida spp. strains, with a low minimum inhibitory concentration (8.2 microgramg/mL)Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds.34391169
Ag/BN NPsThe Ag/BN nanohybrids and amphotericin B-loaded BN and Ag/BN NPs also reveal high fungicidal activity against C. albicans, C. auris, C. parapsilosis, and N. crassa cells.Herein, we demonstrate that Ag/BN NPs and antibiotic-loaded BN and Ag/BN nanoconjugates are promising carriers to fight bacterial and fungal infections34000197
ultra-small silver nanoclusters (rsAg/NCs)we also established that the apoptosis-inducing potential of rsAg/NCs is due to the activation of Ras signaling, which confirms their application in combating FCZ-resistant C. albicans infections.Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated.30769763