Antifungal Phytochemicals and Natural Products

                                                                                                                                                                                                                                  Download data

4-Cyclopentene-1,3-dione from Feijoa ( Acca sellowiana)IC50? 1-2 microM against human-pathogenic Candida speciesBioactivity-Guided Metabolite Profiling of Feijoa ( Acca sellowiana) Cultivars Identifies 4-Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis. 29546758
Acetone Lichen ExtractsSeven extracts displayed both anti-maturation and anti-biofilm activities (half maximal inhibitory concentrations IC50_mat?and IC50_biof?? 100 microg/mL);?Evernia prunastri?and?Ramalina fastigiata?were the most promising lichens (IC50_mat?< 4 microg/mL and IC50_biof?< 10 microg/mL).Antifungal and Anti-Biofilm Activities of Acetone Lichen Extracts against Candida albicans28422057
Aqueous and hydroethanolic extracts from Psidium brownianum Mart ex DC. and Psidium guajava L. A synergistic effect was observed in the combination of fluconazole with Psidium brownianum extracts against all Candida strains. However, for Psidium guajava extracts the synergistic effect was produced mainly against the Candida albicans LM77 and Candida tropicalis INCQS 400042 strains Our results indicated that both P.?brownianum and P.?guajava extracts are effective on potentiating the effect of fluconazole, and therefore, these plants have the potential for development of new effective drugs for treating fungal infections. 27085299
BeauvericinInhibits TOR signaling in Candida albicans, potentiates the activity of azole antifungals against azole-resistant Candida isolates via inhibition of multidrug efflux Here, we explore a powerful strategy to enhance antifungal efficacy against leading human fungal pathogens by using the natural product beauvericin.27736764
BeauvericinTargets multidrug efflux and TOR signaling Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. There is an urgent need for new strategies to treat invasive fungal infections, which are a leading cause of human mortality. Here, we establish two activities of the natural product beauvericin, which potentiates the activity of the most widely deployed class of antifungal against the leading human fungal pathogens, blocks the emergence of drug resistance, and renders antifungal-resistant pathogens responsive to treatment in mammalian infection models.27571477
Benzo[c]phenanthridine alkaloids from Chelidonium majus Linn [8-hydroxydihydrosanguinarine (1) and 8-hydroxydihydrochelerythrine (2), Dihydrosanguinarine (3), dihydrochelerythrine (4), sanguinarine (5) and chelerythrine (6)]Of the six compounds determined, (1) and (2) demonstrated potent activity against clinical drug-resistant yeast isolates with the MIC ranges of 2-80 and 4-100 microg/mL, respectively. (3), (4), (5) and (6) had some degree of antifungal activitThe overall results provided important information for the potential application of the 8-hydroxylated alkaloids from Chelidonium majus in the therapy of serious infection caused by drug-resistant fungi.19647059
Brown Brazilian propolis (Apis mellifera)Sporothrix brasiliensis were sensitive to brown propolis between MIC values of 0.19-1.56 mg/mL, including the itraconazole-resistant isolates, whereas the MFC values of propolis were from 0.78 to greater than 3.125 mg/mL Brown Brazilian propolis is a promising antifungal candidate against sporotrichosis and more studies need to be undertaken to evaluate its safe use to understand its efficacy. 28219829
Carica papaya Linn. seed essential oil?The EO showed inhibitory effect against all the tested Candida strains including C. albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropical with inhibition zone diameters in the range of 14?2-33?2 mm, the minimal inhibitory concentrations (MICs) in the range of 4?0-16?0 microg ml-1?and the minimum fungicidal concentrations (MFCs) in the range of 16?0-64?0 microg ml-1?. Carica Papaya may be recognized as a possible new source of natural antifungal agents. 28052349
Carvacrol?Carvacrol has antifungal activity in comparison to voriconazole (VCZ) (MIC 0?5, 0?25 micro g ml-1?respectively) Assessment of carvacrol for control of avian aspergillosis in intratracheally challenged chickens in comparison to voriconazole with a reference on economic impact. AIM: This study was designed to investigate the efficacy of essential oils as an alternative prophylaxis and treatment for avian aspergillosis.28795522
Enhalus acoroides leaf extract?Activity against C. albicans and E. coli, reduce bacterial and fungal coverage by 60.9 and 73.9%, respectively; affect bacterial biofilm maturation and promote dispersion, up to 70%, in fungal biofilm; increase luminescence in Vibrio harveyi by 25.8% E. acoroides leaf extract proved to be the most promising extract among those tested.29843708
Essential Oil From Salvia mirzayanii LeavesThe MIC95 were 0.03 to 0.5 microL/mL and 16 to 128 microL/mL for gram-positive and gram-negative bacteria, respectively, MIC50 0.03 to 1 microL/mL for yeast Chemical Composition and Antimicrobial Activities of the Essential Oil From Salvia mirzayanii Leaves. Resistance of many pathogens to available drugs is a global challenge and is leading to growing interest in natural alternative products.28689440
Ethyl acetate extract of the herb Dalea formosa of the American SouthwestActivity against azole-sensitive and azole-resistant isolates Modulation of the antifungal activity of new medicinal plant extracts active on Candida glabrata by the major transporters and regulators of the pleiotropic drug-resistance network in Saccharomyces cerevisiae. The increased incidence of drug-resistant fungal infections, a process in which active efflux plays an important role, calls for the development of new treatments.19216644
Globiferin isolated from root extracts of Cordia globifera and its derivativesAntimalarial, antifungal, and cytotoxic activities Biomimetic transformation and biological activities of Globiferin, a terpenoid benzoquinone from Cordia globifera. A new 10-membered ring meroterpene (1), named globiferin, was isolated from root extracts of Cordia globifera. Biomimetic transformations of 1 and its derivatives, either by acid cyclization or by Cope rearrangement, provided information relating to the biogenesis of cordiachromes A-C. Globiferin (1) underwent Cope rearrangement upon refluxing in xylene and DMSO-d(6) to yield cordiachrome C (3) and cordiaquinol C (4), respectively.19368377
Isoflavonoids, sedonans A-F (1-6), a new but-2-enolide, 4'-O-methylpuerol A (7), and the new pterocarpan ent-sandwicensin (8) from the root extract of Dalea formosaMIC = 20 microM of 1 against C. glabrata, Sedonans A-F and ent-sandwicensin active against Saccharomyces cerevisiae strains that express differing ABC transporter-associated resistance mechanisms,We observed strong antifungal growth inhibitory activity in the methanol extract of Dalea formosa roots.23631483
IWF1 and IWF2, proteins isolated from the intercellular washing fluid (IWF) of sugar beet leaves Both proteins show strong in vitro antifungal activity against Cercospora beticola, the casual agent of leaf spot disease in sugar beet New antifungal proteins from sugar beet (Beta vulgaris L.) showing homology to non-specific lipid transfer proteins. Two novel, nearly identical antifungal proteins, IWF1 and IWF2, were isolated from the intercellular washing fluid (IWF) of sugar beet leaves.8790287
Lyophilized aqueous extract of the leaves of Acca sellowiana (O.berg) Burret (Myrtaceae) Candida glabrata showed the lowest MIC values (500-3.90 microg/mL)Reversal of fluconazole resistance induced by a synergistic effect with Acca sellowiana in Candida glabrata strains27050162
Methanolic extract of scapes of Syngonanthus nitens (S. nitens extract [SNE]) and an SNE-loaded liquid crystal precursor mucoadhesive systems (LCPM)Activity against Candida krusei, SNE was active against all strains studied, with minimum inhibitory concentration values ranging from 125 to 62.5 microg/mL; after incorporating SNE into F (FE), these values decreased to 62.5 to 31.2 microg/mL, demonstrating that incorporation into the formulation potentiated the action of SNE. Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Vaginal infections caused by Candida krusei are a problem of extreme complexity due to the intrinsic resistance to azole drugs. Therefore, the objective of this study was to evaluate the potential of the methanolic extract of scapes of S. nitens (S. nitens extract [SNE]) and an SNE-loaded LCPM against C. krusei as prophylaxis for vulvovaginal candidiasis. SNE was active against all strains studied, with minimum inhibitory concentration values ranging from 125 to 62.5 ?g/mL; after incorporating SNE into F (FE), these values decreased to 62.5 to 31.2 ?g/mL, demonstrating that incorporation into the formulation potentiated the action of SNE.26719688
Origanum vulgare (oregano), Pinus sylvestris (pine), and Thymus vulgaris (thyme red) EOs, and their componentsActivity against Cryptococcus neoformans To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains29724221
p-coumaroyl-hydroxyagmatine (p-CHA) from barley leaf Antifungal activity both in vitro and in vivo Structural analysis identified this compound as a novel phenolic conjugate, p-coumaroyl-hydroxyagmatine (p-CHA). p-CHA but not the nonhydroxylated derivative p-coumaroylagmatine exhibited antifungal activity both in vitro and in vivo.9535889
Plant-derived essential oils [Pelargonium graveolens (Geraniaceae) (PG-EO) , linalool, geraniol]PG-EO most effective oil, treatments with PG-EO, linalool, and geraniol significantly reduced the number of viable biofilm cells and inhibited biofilm formation in Candida species Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells. PG-EO, geraniol, and linalool were not toxic to normal human lung fibroblasts (GM07492A) at the concentrations they were active against C. tropicalis Together, our results indicated that C. tropicalis is susceptible to treatment with PG-EO, geraniol, and linalool, which could become options to prevent or treat this infection.26868902
Quercetin (QCT)64 micro g/mL QCT and/or 128 ?g/mL FCZ could be synergistic against 10 FCZ-resistant planktonic and 17 biofilm cells of C. albicans, and inhibit fungal adherence, cell surface hydrophobicity (CSH), flocculation, yeast-to-hypha transition, metabolism, thickness and dispersion of biofilms Together with these results, it could be demonstrated that QCT could be a favorable antifungal agent and a promising synergist with FCZ in the clinical management of VVC caused by C. albicans biofilm. 27915337
Selected secondary metabolites from Chilean Calceolaria integrifolia sensu lato complexMixtures of isorhamnetin/dunnione/kaempferol/ferulic/gallic acid in various combinations were found to have the most potent bactericidal and fungicidal activity with MFC between 10 and 50 microg/ml. Quercetin was found to be the most potent fungistatic single compound with an MIC of 15 microg/ml.Biopesticides from plants: Calceolaria integrifolia s.l24893349
Sodium lignosulfonate (LIG)MIC against Candida spp. was found to be 64-128 micro g/ml.Deciphering the role of Sodium Lignosulfonate against Candida spp. as persuasive anticandidal agent. In the race of Candida therapeutics, the revelation of the antifungal potential of such natural compounds might impact and diversify the discovery and development of novel antifungal agent. 28962848
Solasodine-3-O-?-d-glucopyranoside (SG) isolated from the medicinal plant Solanum nigrum LIn vitro, SG displayed potent fungicidal activity against both azole-sensitive and azole-resistant Candida albicans strains in Spider medium with its MICs of 32 ?g/ml Solasodine-3-O-?-d-glucopyranoside kills Candida albicans by disrupting the intracellular vacuole. In?vitro, SG displayed potent fungicidal activity against both azole-sensitive and azole-resistant Candida albicans strains in Spider medium with its MICs of 32??g/ml.28552788
Steroid saponins from Tribulus terrestris L. (TTS-12, TTS-15)TTS-12 and TTS-15 were very active against fluconazole-resistant C. albicans (MIC(80)=4.4, 9.4 microg/ml), C. neoformans (MIC(80)=10.7, 18.7 microg/ml) and inherently resistant C. krusei (MIC(80)=8.8, 18.4 microg/ml) In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against fluconazole-resistant fungal pathogens. Antifungal activity of natural products is being studied widely.16327151
Thymus daenensis and Silybum marianum extracts with Ag-NPsActivity at?12.5 to 50 mg/mL against Staphylococcus aureus (S. aureus, Gram-positive organism) and Escherichia coli (E. coli, Gram-negative organism), and fungal strains were Aspergillus oryzae (A. oryzae) and Candida albicans (C. albicans).Ultrasound-assisted extraction of antimicrobial compounds from Thymus daenensis and Silybum marianum: Antimicrobial activity with and without the presence of natural silver nanoparticles29429729
Usnic AcidThe biofilm inhibitory concentration of usnic acid (4 ?g/mL) exhibited a significant biofilm inhibition, 71.08 % for azole-resistant and 87.84 % for azole-sensitive C. albicans strains Our results suggest that usnic acid could be an alternative for the treatment of Candida infections, which deserves further investigation. 27648556
Xylaria sp. BIOTEC culture collection (BCC) 1067?Promising antifungal effect against yeast Saccharomyces cerevisiae with minimal inhibitory concentration?and minimal fungicidal concentration of 500 and 1000 mg/l, respectively, strong synergy with fractional inhibitory concentration index value of 0.185 for the combination of 60.0 and 0.5 mg/l of extract and ketoconazole, respectively BCC 1067 extract is a potentially valuable source of novel antifungals. 28361556
Zingiber officinale ExtractThe findings of the present study indicate that ginger extract has good antifungal and antibiofilm formation by fungi against C. albicans and C. Krusei. Concentrations between 0.625 mg/mL and 5 mg/mL had the highest antibiofilm and antifungal effectsSurvey of the Antibiofilm and Antimicrobial Effects of Zingiber officinale (in Vitro Study)27127591