Antiparasitic Peptides

                                                                                                                                                                                                                                  Download data

Urocortin II (UCNII)Antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria and tropical parasites of the genus Leishmania.Did not affect mammalian cell viability.Therefore, UCNII could be considered as an ancient highly-conserved host peptide involved in the natural antimicrobial defense and emerge as an attractive alternative to current treatments for microbial disorders with associated drug resistances.24249730
temporin-Sha analogue [K3]SHaExert leishmanicidal activity via a primary membranolytic mechanism but can also trigger apoptotis-like deathInsight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent. Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens.28319176
BMAP-28 and two of its isomers the D-amino acid form (D-BMAP-28) and the retro-inverso form (RI-BMAP-28)D-BMAP-28 appears to be the most potent antiparasitic of the three isomers against wild type L. major promastigotes and amastigotesAn MTS viability assay was utilized to show the potent antiparasitic activity of BMAP-28 and its protease resistant isomers against L. major promastigotes in vitro.21655347
Antimicrobial peptide LL-37 and the three synthetic peptides E6, L-1018, and RI-1018Leishmanicidal activity against promastigotes and intramacrophage amastigotes of Leishmania donovani and Leishmania majorThe results suggest that RI-1018 E6 and LL-37 are promising peptides to develop further into components for antileishmanial therapy.26883699
Combination of alkylphosphocholines with peptaibolsAntileishmanial activityFurthermore, they revealed the importance of exploring novel classes of bioactive compounds such as peptaibols and demonstrated for the first time that they can act in synergy with currently used antileishmanial drugs to improve the therapeutic outcome.29631127